"At this time, suggesting changes to the FDA-authorized dosing or schedules of these vaccines is premature and not rooted solidly in the available evidence," Dr. Stephen Hahn, FDA commissioner, and Dr. Peter Marks, director of the FDA's Center for Biologics Evaluation and Research, said in a statement. "Without appropriate data supporting such changes in vaccine administration, we run a significant risk of placing public health at risk."
However, we know how to make decisions under uncertainty: minimize expected error costs or maximize expected value. The expected benefit of one-dose regime (vaccinating twice as many people with a half dose) is millions of lives.
The FDA has a long and sorry history of delaying medical innovation because type I errors (doing something that turns out to be wrong) are visible and type II errors are not (not doing something that turns out to be right). These bureaucrats seem to be putting their own interests ahead of those of the people they are supposed to protect.
The simplest argument for First Doses First (FDF) is that 2*0.8>.95, i.e. two vaccinated people confers more immunity than one double vaccinated person. But there is more to it than that. Perhaps more important is that with FDF we will lower R more quickly and reach herd immunity sooner.
Here’s an extreme but telling example. Suppose you have a pop of 300 million, need 2/3 to get to herd immunity and you have 100m doses and can vaccinate 100m a month. Then with FDF you vaccinate 100m in first month and a new 100m in the second month and then you are “done.” i.e. you can then do 2nd doses more or less at leisure since you are at herd immunity (yes, I know about overshooting, this is a simple example). If instead you do second doses you vaccinate 100m in first month and the same 100m in the second month which leaves 100 million at risk for another month. Under second doses you don’t reach herd immunity until the third month. Thus, under FDF you save a 100m infection-month which is a big deal.
This is a well-known incentive problem: unless we evaluate bureaucrats based on expected value, not on whether they commit Type I errors, they will respond accordingly.
To know more about Chief Dr Lucky you can visit his website (https://chiefdrluckyherbaltherapy.wordpress.com/)
ReplyDeleteA friend that suffered from Herpes and was cure with the help of this great herbal doctor Chief Lucky so i decided to contact him for help in getting rid of my families genital herpes virus 1/2 which i did and all i was told to provide was just some useful information and some materials used in preparation of the natural cure and that i did and now i am the happiest person on earth because i am writing this testimony of mine with joy and happiness in my heart to the whole world to know that natural remedy is real because i am a living testimony of Chief Lucky traditional herbal cure and i want you all to contact Chief Lucky via his email: chiefdrlucky@gmail.com or WhatsApp him +2348132777335 am sure he will help you too.
Greatest thanks to Dr Oyagu for his herbal drugs that he prepared for me and when I start using it in just 2weeks I was completely cured and that ended my HERPES SIMPLEX 1&2 DISEASE i am so happy and grateful to Dr Oyagu . after reading about him on a testimony of Jason Cash on a blogger. I knew suddenly Dr Oyagu was the right Doctor to cure my HERPES SIMPLEX 1&2 DISEASE. I discuss with Dr Oyagu and he prepared a herbal medicine for me and when it got sent to me in south Korean . I used the herbal medicine and 2weeks and i went to check up again. after 15years of suffering from HERPES SIMPLEX 1&2 at last i am smiling once again. Dr Oyagu also has remedy to others disease like COLD SORES,HIV/AIDS,DIABETES.CANCER,HIGH BLOOD PRESSURE AND MANY MORE. I oblige everyone to contact this powerful herbalist Dr Oyagu and be free from your suffering. contact his WhatsApp line: +2348101755322 or visit his Website https://oyaguspellcaster.wixsite.com/oyaguherbalhome Email:Oyaguherbalhome@gmail.com
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I got diagnose of herpes virus last year, and i was taking some drugs prescribed for me by my family doc the drugs could not work and the herpes in my system was very terrifying that i was so depressed the good news is that i never gave up in searching for natural cure for herpes virus ,cause i believe so much in herbal medication.. One faithful morning i read a comment from a lady called Destiny Hudson on how she was cured with natural herbs made by DR.OYAGU from somewhere is West Africa, i immediately copied out his contact email via oyaguherbalhome@gmail.com and explain all my herpes problem to him via his email. the big truth is that it took just two week for his herbal medication to cure me completely without side affect. Till date am herpes virus free and all thanks to Dr OYAGU for his good deeds for me, Once again am very happy to share this great testimony of DR OYAGU cure hurry up now and contact him via his email address (oyaguherbalhome@gmail.com Call & WhatsApp him on (+2348101755322 ) and see what he can do
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